Characterization of FOXN1 mutation-mediated immune deficiency

In this episode, Nicolai van Oers and colleagues demonstrate that compound heterozygous mutations in FOXN1 result in a combined immunodeficiency in patients that is distinct Nude/SCID phenotypes.

JCI's Conversations with Giants in Medicine: Lucy Shapiro

Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the genetic and molecular decision-making process that directs an asymmetric cell division yielding daughter cells with different cell fates. Shapiro’s insights helped launch the field of systems biology, and more recently, her work has led to the development of novel antifungal drugs. 

Creating and publishing a scientific masterpiece

JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.

Breast milk-derived alkylglycerols support beige adipose tissue

In this episode, Tamás Röszer and colleagues demonstrate that breast-milk-derived alkylglycerols preserve beige adipocytes to protect against obesity.

JCI's Conversations with Giants in Medicine: George Church

JCI Editor at Large Ushma S. Neill interviews the geneticist, innovator, and entrepreneur George Church, of Harvard and MIT. Dr. Church developed the methods for the first genome sequencing, and his subsequent work has brought down the price of sequencing over 10-million-fold. His was one of the two research groups that first got CRISPR/Cas9 to work for precise gene editing in human cells by a homologous recombination, and he has been behind countless other scientific innovations and disruptions, specifically in the world of precision genome sequencing.