Conversations with Giants in Medicine
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Mechanisms Underlying the Metabolic Syndrome (Oct 2019)
Reparative Immunology (Jul 2019)
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Biology of familial cancer predisposition syndromes (Feb 2019)
Mitochondrial dysfunction in disease (Aug 2018)
Lipid mediators of disease (Jul 2018)
Cellular senescence in human disease (Apr 2018)
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Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
In this episode, Neil Bhowmick and colleagues reveal that epigenetic changes in prostate cancer-associated fibroblasts promote tumor growth and development of resistance to androgen depravation….
Published September 4, 2018
Vitamin D3 metabolite enables bone fracture repair
In this episode, René St-Arnaud and colleagues identify a 24R,25-dihydroxyvitamin D3–dependent pathway involved in bone repair...
Published July 16, 2018
CaMK4 drives podocyte injury
In this episode, George Tsokos and colleagues reveal that CaMK4-mediated signaling directly promotes podocyte dysfunction…
Published July 9, 2018
Altered abiraterone metabolism in individuals with HSD3B1 variant
Nima Sharifi and colleagues demonstrate altered abiraterone metabolism in individuals with the HSD3B1(1245C) variant that may influence clinical response…
Published June 25, 2018
JAK inhibitor treatment shows benefit for patients with interferonopathies
In this episode, Gina A. Montealegre Sanchez, Raphaela Goldbach-Mansky, and colleagues demonstrate that JAK1/2 inhibitor baricitinib improves clinical manifestations in a small cohort of patients with interferonopathies…
Published June 11, 2018
REV-ERBα controls the clock in the lung
In this episode, David Ray, Marie Pariollaud and colleagues identify REV-ERBα as a critical regulator of rhythmic inflammatory responses in the lung…
Published April 30, 2018
Immune tolerance-like pathway inhibits repair following white matter injury
Stephen Back and colleagues identify an immune tolerance-like pathway that prevents repair after white matter injury…
Published April 16, 2018
Vaginal epithelial shedding mediates ascending group B streptococcus infection
In this episode, Lakshmi Rajagopal provide evidence that group B streptococcus-induced exfoliation of the vaginal epithelium promotes ascending infection…
Published April 9, 2018
A role for plasminogen activator inhibitor type 1 in skin fibrosis
In this episode, Colin Jamora, Neha Pincha, and colleagues demonstrate a role for plasminogen activator inhibitor type 1 in driving fibrogenesis in a murine model of skin fibrosis…
Published March 26, 2018
CD163+ macrophages serve pathogenic role in atherosclerosis
In this episode Aloke Finn, Liang Guo and colleagues reveal that a population of alternatively activated CD163+ macrophages, previously thought to be atheroprotective, are instead pathogenic….
Published February 19, 2018
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American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)
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