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Usage Information

Embryonic stem cells as sources of donor-independent platelets
Matthew C. Canver, … , Daniel E. Bauer, Stuart H. Orkin
Matthew C. Canver, … , Daniel E. Bauer, Stuart H. Orkin
Published June 1, 2015; First published May 11, 2015
Citation Information: J Clin Invest. 2015;125(6):2261-2263. https://doi.org/10.1172/JCI82348.
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Category: Commentary

Embryonic stem cells as sources of donor-independent platelets

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Abstract

The creation of a donor-independent source of platelets has been challenging; however, recent advances show growing promise for alternative platelet sources. Pluripotent stem cells have the capacity to differentiate into mature megakaryocytes with the ability to produce functional platelets. In this issue of JCI, Noh et al. provide a proof-of-principle demonstration that embryonic stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. This study emphasizes the importance of precise regulation of gene expression for regenerative medicine applications.

Authors

Matthew C. Canver, Daniel E. Bauer, Stuart H. Orkin

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Usage data is cumulative from December 2018 through December 2019.

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