Commentary 10.1172/JCI125985

Colorectal cancer: the APC-lncRNA link

Pat J. Morin

Abramson Cancer Center and Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Address correspondence to: Pat J. Morin, Abramson Cancer Center and Department of Ob/Gyn, University of Pennsylvania, 3400 Civic Center Blvd., PCAM South Pavilion, 12-133, Philadelphia, Pennsylvania 19104, USA. Phone: 215.220.9681; Email: patmorin@upenn.edu.

Find articles by Morin, P. in: JCI | PubMed | Google Scholar | Orcid 24x24

First published January 14, 2019 - More info

Published in Volume 129, Issue 2 on February 1, 2019
J Clin Invest. 2019;129(2):503–505. https://doi.org/10.1172/JCI125985.
Copyright © 2019, American Society for Clinical Investigation

First published January 14, 2019 - Version history

The adenomatous polyposis coli (APC) gene plays, among other things, a crucial role in the regulation of cell proliferation and survival through its ability to regulate canonical Wnt signaling. In this issue of the JCI, Wang et al. provide an intriguing new mechanism for APC function involving the regulation of a novel long noncoding RNA (lncRNA), leading to changes in exosome production. APC signaling via this novel pathway can regulate cell proliferation and invasion as well as angiogenesis. In addition to enhancing our understanding of APC function, this new mechanism is of particular clinical significance, as it may provide additional targets for the treatment of APC-mutated cancers.

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