[HTML][HTML] Evidence That the DNA Mismatch Repair System Removes 1-Nucleotide Okazaki Fragment Flaps*♦
LY Kadyrova, BK Dahal, FA Kadyrov - Journal of Biological Chemistry, 2015 - ASBMB
The DNA mismatch repair (MMR) system plays a major role in promoting genome stability
and suppressing carcinogenesis. In this work, we investigated whether the MMR system is
involved in Okazaki fragment maturation. We found that in the yeast Saccharomyces
cerevisiae, the MMR system and the flap endonuclease Rad27 act in overlapping pathways
that protect the nuclear genome from 1-bp insertions. In addition, we determined that purified
yeast and human MutSα proteins recognize 1-nucleotide DNA and RNA flaps. In …
and suppressing carcinogenesis. In this work, we investigated whether the MMR system is
involved in Okazaki fragment maturation. We found that in the yeast Saccharomyces
cerevisiae, the MMR system and the flap endonuclease Rad27 act in overlapping pathways
that protect the nuclear genome from 1-bp insertions. In addition, we determined that purified
yeast and human MutSα proteins recognize 1-nucleotide DNA and RNA flaps. In …