Serum amyloid A (SAA) is a major acute-phase protein and a precursor of amyloid A, the
deposit of which leads to amyloidosis. Different alleles exist in SAA1, a predominant form of
the human SAA gene family. Emerging evidence has shown correlations between these
alleles and diseases including familiar Mediterranean fever and amyloidosis. However, it
remains unclear how the proteins encoded by these SAA1 alleles act differently. Here we
report the characterization of proteins encoded by SAA1. 1, SAA1. 3, and SAA1. 5, in …