[HTML][HTML] Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist
R Hegde, SM Srinivasula, M Ahmad… - Journal of Biological …, 1998 - ASBMB
We identified and cloned a novel murine member of the pro-apoptotic Bcl-2 family. This
protein, designated Blk, is structurally and functionally related to human Bik and localized to
the mitochondrial membrane. Blk contains a conserved BH3 domain and can interact with
the anti-apoptotic proteins Bcl-2 and Bcl-xL. Ectopic expression of Blk in mammalian cells
induces apoptosis, which can be inhibited by mutations in the BH3 domain and by
overexpression of Bcl-2 or Bcl-xL but not by CrmA. The apoptotic activity of Blk is also …
protein, designated Blk, is structurally and functionally related to human Bik and localized to
the mitochondrial membrane. Blk contains a conserved BH3 domain and can interact with
the anti-apoptotic proteins Bcl-2 and Bcl-xL. Ectopic expression of Blk in mammalian cells
induces apoptosis, which can be inhibited by mutations in the BH3 domain and by
overexpression of Bcl-2 or Bcl-xL but not by CrmA. The apoptotic activity of Blk is also …