IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain
chronic diseases although the underlying mechanisms are poorly understood. We found that
IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house
dust mite exposure was enhanced in noxa−/− compared with noxa+/+ mice. Noxa
expression blocked transforming necrosis factor alpha (TNF-α)-induced nuclear
translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and …