[HTML][HTML] Minimal interleukin 6 (IL-6) receptor stalk composition for IL-6 receptor shedding and IL-6 classic signaling
P Baran, R Nitz, J Grötzinger, J Scheller… - Journal of Biological …, 2013 - ASBMB
Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) is coordinated by membrane-bound
and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-
signaling, respectively. The soluble IL-6R is mainly generated by ADAM10-and ADAM17-
mediated ectodomain shedding. Little is known about the role of the 52-amino acid-residue-
long IL-6R stalk region in shedding and signal transduction. Therefore, we generated and
analyzed IL-6R stalk region deletion variants for cleavability and biological activity. Deletion …
and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-
signaling, respectively. The soluble IL-6R is mainly generated by ADAM10-and ADAM17-
mediated ectodomain shedding. Little is known about the role of the 52-amino acid-residue-
long IL-6R stalk region in shedding and signal transduction. Therefore, we generated and
analyzed IL-6R stalk region deletion variants for cleavability and biological activity. Deletion …