[HTML][HTML] Novel insights into interleukin 6 (IL-6) cis-and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex
M Lacroix, F Rousseau, F Guilhot, P Malinge… - Journal of Biological …, 2015 - ASBMB
The IL-6 signaling complex is described as a hexamer, formed by the association of two IL-6·
IL-6 receptor (IL-6R)· gp130 trimers, with gp130 being the signal transducer inducing cis-
and trans-mediated signaling via a membrane-bound or soluble form of the IL-6R,
respectively. 25F10 is an anti-mouse IL-6R mAb that binds to both membrane-bound IL-6R
and soluble IL-6R with the unique property of specifically inhibiting trans-mediated signaling
events. In this study, epitope mapping revealed that 25F10 interacts at site IIb of IL-6R but …
IL-6 receptor (IL-6R)· gp130 trimers, with gp130 being the signal transducer inducing cis-
and trans-mediated signaling via a membrane-bound or soluble form of the IL-6R,
respectively. 25F10 is an anti-mouse IL-6R mAb that binds to both membrane-bound IL-6R
and soluble IL-6R with the unique property of specifically inhibiting trans-mediated signaling
events. In this study, epitope mapping revealed that 25F10 interacts at site IIb of IL-6R but …