[HTML][HTML] Nucleolin acts as the receptor for C1QTNF4 and supports C1QTNF4-mediated innate immunity modulation
SK Vester, RL Beavil, S Lynham, AJ Beavil… - Journal of Biological …, 2021 - ASBMB
The C1q and TNF related 4 (C1QTNF4) protein is a structurally unique member of the
C1QTNF family, a family of secreted proteins that have structural homology with both
complement C1q and the tumor necrosis factor superfamily. C1QTNF4 has been linked to
the autoimmune disease systemic lupus erythematosus through genetic studies; however,
its role in immunity and inflammation remains poorly defined and a cell surface receptor of
C1QTNF4 has yet to be identified. Here we report identification of nucleolin as a cell surface …
C1QTNF family, a family of secreted proteins that have structural homology with both
complement C1q and the tumor necrosis factor superfamily. C1QTNF4 has been linked to
the autoimmune disease systemic lupus erythematosus through genetic studies; however,
its role in immunity and inflammation remains poorly defined and a cell surface receptor of
C1QTNF4 has yet to be identified. Here we report identification of nucleolin as a cell surface …