[HTML][HTML] CXCL13 expression in the gut promotes accumulation of IL-22-producing lymphoid tissue-inducer cells, and formation of isolated lymphoid follicles
F Marchesi, AP Martin, N Thirunarayanan, E Devany… - Mucosal …, 2009 - Elsevier
The chemokine CXCL13 is overexpressed in the intestine during inflammation. To mimic this
condition, we created transgenic mice-expressing CXCL13 in intestinal epithelial cells.
CXCL13 expression promoted a marked increase in the number of B cells in the lamina
propria and an increase in the size and number of lymphoid follicles in the small intestine.
Surprisingly, these changes were associated with a marked increase in the numbers of
RORγt+ NKp46− CD3− CD4+ and RORγt+ NKp46+ cells. The RORγt+ NKp46− CD3− CD4+ …
condition, we created transgenic mice-expressing CXCL13 in intestinal epithelial cells.
CXCL13 expression promoted a marked increase in the number of B cells in the lamina
propria and an increase in the size and number of lymphoid follicles in the small intestine.
Surprisingly, these changes were associated with a marked increase in the numbers of
RORγt+ NKp46− CD3− CD4+ and RORγt+ NKp46+ cells. The RORγt+ NKp46− CD3− CD4+ …