FBXO38 drives PD-1 to destruction
TM Serman, MU Gack - Trends in Immunology, 2019 - cell.com
TM Serman, MU Gack
Trends in Immunology, 2019•cell.comAberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to
promote tumor progression. A recent study (Nature 2018; 564: 130–135) has now identified
the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells,
providing a novel mechanism for potential use in cancer immunotherapy.
promote tumor progression. A recent study (Nature 2018; 564: 130–135) has now identified
the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells,
providing a novel mechanism for potential use in cancer immunotherapy.
Aberrant expression of T cell-resident programmed cell death protein-1 (PD-1) is known to promote tumor progression. A recent study (Nature 2018;564:130–135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-1 protein turnover in T cells, providing a novel mechanism for potential use in cancer immunotherapy.
cell.com
