[HTML][HTML] Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members
J Suzuki, T Fujii, T Imao, K Ishihara, H Kuba… - Journal of Biological …, 2013 - ASBMB
Asymmetrical distribution of phospholipids between the inner and outer plasma membrane
leaflets is disrupted in various biological processes. We recently identified TMEM16F, an
eight-transmembrane protein, as a Ca 2+-dependent phospholipid scramblase that exposes
phosphatidylserine (PS) to the cell surface. In this study, we established a mouse
lymphocyte cell line with a floxed allele in the TMEM16F gene. When TMEM16F was
deleted, these cells failed to expose PS in response to Ca 2+ ionophore, but PS exposure …
leaflets is disrupted in various biological processes. We recently identified TMEM16F, an
eight-transmembrane protein, as a Ca 2+-dependent phospholipid scramblase that exposes
phosphatidylserine (PS) to the cell surface. In this study, we established a mouse
lymphocyte cell line with a floxed allele in the TMEM16F gene. When TMEM16F was
deleted, these cells failed to expose PS in response to Ca 2+ ionophore, but PS exposure …