[HTML][HTML] Tag7 (PGLYRP1) in complex with Hsp70 induces alternative cytotoxic processes in tumor cells via TNFR1 receptor
DV Yashin, OK Ivanova, NV Soshnikova… - Journal of Biological …, 2015 - ASBMB
Tag7 (also known as peptidoglycan recognition protein PGRP-S, PGLYRP1), an innate
immunity protein, interacts with Hsp70 to form a stable Tag7-Hsp70 complex with cytotoxic
activity against some tumor cell lines. In this study, we have analyzed the programmed cell
death mechanisms that are induced when cells interact with the Tag7-Hsp70 complex,
which was previously shown to be released by human lymphocytes and is cytotoxic to
cancer cells. We show that this complex induces both apoptotic and necroptotic processes in …
immunity protein, interacts with Hsp70 to form a stable Tag7-Hsp70 complex with cytotoxic
activity against some tumor cell lines. In this study, we have analyzed the programmed cell
death mechanisms that are induced when cells interact with the Tag7-Hsp70 complex,
which was previously shown to be released by human lymphocytes and is cytotoxic to
cancer cells. We show that this complex induces both apoptotic and necroptotic processes in …