[HTML][HTML] Protein kinase C-δ (PKC-δ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
It is well established that engagement of the Type I interferon (IFN) receptor results in
activation of JAKs (Janus kinases), which in turn regulate tyrosine phosphorylation of STAT
proteins. Subsequently, the IFN-dependent tyrosine-phosphorylated/activated STATs
translocate to the nucleus to regulate gene transcription. In addition to tyrosine
phosphorylation, phosphorylation of Stat1 on serine 727 is essential for induction of its
transcriptional activity, but the IFNα-dependent serine kinase that regulates such …
activation of JAKs (Janus kinases), which in turn regulate tyrosine phosphorylation of STAT
proteins. Subsequently, the IFN-dependent tyrosine-phosphorylated/activated STATs
translocate to the nucleus to regulate gene transcription. In addition to tyrosine
phosphorylation, phosphorylation of Stat1 on serine 727 is essential for induction of its
transcriptional activity, but the IFNα-dependent serine kinase that regulates such …