[HTML][HTML] Antigen‐specific in vitro expansion of factor VIII‐specific regulatory T cells induces tolerance in hemophilia A mice
BM Smith, MJ Lyle, AC Chen, CH Miao - Journal of Thrombosis and …, 2020 - Elsevier
Background Following protein replacement therapy, one‐third of severe hemophilia A
patients develop antibodies to factor VIII (FVIII), which also hinders the efficacy of gene
therapy. Regulatory T cells (Tregs) have a naturally suppressive function that potentially
reduces the immune response to FVIII therapy. Furthermore, antigen‐specific Tregs are
functionally much more potent than polyclonal cells. Adoptive transfer of antigen‐specific
Tregs can effectively suppress anti‐FVIII antibody responses. Objective Develop a clinically …
patients develop antibodies to factor VIII (FVIII), which also hinders the efficacy of gene
therapy. Regulatory T cells (Tregs) have a naturally suppressive function that potentially
reduces the immune response to FVIII therapy. Furthermore, antigen‐specific Tregs are
functionally much more potent than polyclonal cells. Adoptive transfer of antigen‐specific
Tregs can effectively suppress anti‐FVIII antibody responses. Objective Develop a clinically …