Review of immune tolerance induction in hemophilia A
SJ Schep, REG Schutgens, K Fischer, ML Boes - Blood Reviews, 2018 - Elsevier
At first sight the bleeding disorder hemophilia A seems to have little in common with immune
disorders, but immunology research intersects with other disciplines including hematology.
Nowadays, the most important complication in the treatment of hemophilia A is the
development of neutralizing antibodies (inhibitors) against exogenous administered factor
VIII (FVIII), which occurs in approximately 30% of all patients with severe hemophilia A. This
antibody response renders FVIII replacement therapy ineffective, thereby increasing the risk …
disorders, but immunology research intersects with other disciplines including hematology.
Nowadays, the most important complication in the treatment of hemophilia A is the
development of neutralizing antibodies (inhibitors) against exogenous administered factor
VIII (FVIII), which occurs in approximately 30% of all patients with severe hemophilia A. This
antibody response renders FVIII replacement therapy ineffective, thereby increasing the risk …