Pediatric acute myeloid leukemia: biology and therapeutic implications of genomic variants
K Tarlock, S Meshinchi - Pediatric Clinics, 2015 - pediatric.theclinics.com
Acute myeloid leukemia (AML) is a hematopoietic malignancy that is the culmination of
genetic and epigenetic alterations in the hematopoietic stem/progenitor cells, leading to
dysregulation of critical signal transduction pathways and resulting in the expansion of
undifferentiated myeloid cells. AML can be broadly divided into 2 categories, de novo AML
and secondary AML. Secondary AML refers to evolution of AML subsequent to prior
exposure to cytotoxic therapy or antecedent hematopoietic insufficiency (eg, myelodysplastic …
genetic and epigenetic alterations in the hematopoietic stem/progenitor cells, leading to
dysregulation of critical signal transduction pathways and resulting in the expansion of
undifferentiated myeloid cells. AML can be broadly divided into 2 categories, de novo AML
and secondary AML. Secondary AML refers to evolution of AML subsequent to prior
exposure to cytotoxic therapy or antecedent hematopoietic insufficiency (eg, myelodysplastic …