[HTML][HTML] Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism
MR McGuire, D Mukhopadhyay, SL Myers… - Journal of Biological …, 2021 - ASBMB
Progesterone receptor membrane component 1 (PGRMC1) is a heme-binding protein
implicated in a wide range of cellular functions. We previously showed that PGRMC1 binds
to cytochromes P450 in yeast and mammalian cells and supports their activity. Recently, the
paralog PGRMC2 was shown to function as a heme chaperone. The extent of PGRMC1
function in cytochrome P450 biology and whether PGRMC1 is also a heme chaperone are
unknown. Here, we examined the function of Pgrmc1 in mouse liver using a knockout model …
implicated in a wide range of cellular functions. We previously showed that PGRMC1 binds
to cytochromes P450 in yeast and mammalian cells and supports their activity. Recently, the
paralog PGRMC2 was shown to function as a heme chaperone. The extent of PGRMC1
function in cytochrome P450 biology and whether PGRMC1 is also a heme chaperone are
unknown. Here, we examined the function of Pgrmc1 in mouse liver using a knockout model …