Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice
Major urinary protein-1 (MUP-1) is a low molecular weight secreted protein produced
predominantly from the liver. Structurally it belongs to the lipocalin family, which carries
small hydrophobic ligands such as pheromones. However, the physiological functions of
MUP-1 remain poorly understood. Here we provide evidence demonstrating that MUP-1 is
an important player in regulating energy expenditure and metabolism in mice. Both
microarray and real-time PCR analysis demonstrated that the MUP-1 mRNA abundance in …
predominantly from the liver. Structurally it belongs to the lipocalin family, which carries
small hydrophobic ligands such as pheromones. However, the physiological functions of
MUP-1 remain poorly understood. Here we provide evidence demonstrating that MUP-1 is
an important player in regulating energy expenditure and metabolism in mice. Both
microarray and real-time PCR analysis demonstrated that the MUP-1 mRNA abundance in …
