Analysis of FOXO1A as a candidate gene for type 2 diabetes
The human forkhead box O1A (FOXO1A) gene on chromosome 13q14. 1 is a key
transcription factor in insulin signaling in liver and adipose tissue and plays a central role in
the regulation of key pancreatic β-cell genes including IPF1. We hypothesized that
sequence variants of FOXO1A contribute to the observed defects in hepatic and peripheral
insulin action and altered β-cell compensation that characterize type 2 diabetes (T2DM). To
test this hypothesis, we screened the three exons, 3′ untranslated region, and 5′ flanking …
transcription factor in insulin signaling in liver and adipose tissue and plays a central role in
the regulation of key pancreatic β-cell genes including IPF1. We hypothesized that
sequence variants of FOXO1A contribute to the observed defects in hepatic and peripheral
insulin action and altered β-cell compensation that characterize type 2 diabetes (T2DM). To
test this hypothesis, we screened the three exons, 3′ untranslated region, and 5′ flanking …
