[HTML][HTML] Impaired speech perception in noise with a normal audiogram: No evidence for cochlear synaptopathy and no relation to lifetime noise exposure
In rodents, noise exposure can destroy synapses between inner hair cells and auditory
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced
cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated with
long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to-high
sound levels. This pathophysiology has been suggested to degrade speech perception in
noise (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically …
nerve fibers (“cochlear synaptopathy”) without causing hair cell loss. Noise-induced
cochlear synaptopathy usually leaves cochlear thresholds unaltered, but is associated with
long-term reductions in auditory brainstem response (ABR) amplitudes at medium-to-high
sound levels. This pathophysiology has been suggested to degrade speech perception in
noise (SPiN), perhaps explaining why SPiN ability varies so widely among audiometrically …