Association of lipid fractions with risks for coronary artery disease and diabetes
J White, DI Swerdlow, D Preiss… - JAMA …, 2016 - jamanetwork.com
Importance Low-density lipoprotein cholesterol (LDL-C) is causally related to coronary artery
disease (CAD), but the relevance of high-density lipoprotein cholesterol (HDL-C) and
triglycerides (TGs) is uncertain. Lowering of LDL-C levels by statin therapy modestly
increases the risk of type 2 diabetes, but it is unknown whether this effect is specific to
statins. Objective To investigate the associations of 3 routinely measured lipid fractions with
CAD and diabetes through mendelian randomization (MR) using conventional MR and …
disease (CAD), but the relevance of high-density lipoprotein cholesterol (HDL-C) and
triglycerides (TGs) is uncertain. Lowering of LDL-C levels by statin therapy modestly
increases the risk of type 2 diabetes, but it is unknown whether this effect is specific to
statins. Objective To investigate the associations of 3 routinely measured lipid fractions with
CAD and diabetes through mendelian randomization (MR) using conventional MR and …
