Frequent mutation and nuclear localization of β-catenin in sertoli cell tumors of the testis
F Perrone, A Bertolotti, G Montemurro… - The American journal …, 2014 - journals.lww.com
The Sertoli cell tumor (SCT) of the testis is a sex cord stromal tumor, usually sporadic, rarely
associated with genetic syndromes. Much remains unclear about the molecular genetic
changes involved in SCT and its histogenesis. Recently, nuclear β-catenin immunostaining
has been reported in a case of bilateral SCT, but the molecular basis of the aberrant nuclear
β-catenin expression remains uncertain. In the present study, β-catenin
immunohistochemical assay and mutational analysis of exon 3 of the CTNNB1 gene by …
associated with genetic syndromes. Much remains unclear about the molecular genetic
changes involved in SCT and its histogenesis. Recently, nuclear β-catenin immunostaining
has been reported in a case of bilateral SCT, but the molecular basis of the aberrant nuclear
β-catenin expression remains uncertain. In the present study, β-catenin
immunohistochemical assay and mutational analysis of exon 3 of the CTNNB1 gene by …
