[HTML][HTML] Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China

W Liang, W Guan, R Chen, W Wang, J Li, K Xu… - The lancet …, 2020 - thelancet.com
W Liang, W Guan, R Chen, W Wang, J Li, K Xu, C Li, Q Ai, W Lu, H Liang, S Li, J He
The lancet oncology, 2020thelancet.com
China and the rest of the world are experiencing an outbreak of a novel betacoronavirus
known as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). 1 By Feb 12,
2020, the rapid spread of the virus had caused 42 747 cases and 1017 deaths in China and
cases have been reported in 25 countries, including the USA, Japan, and Spain. WHO has
declared 2019 novel coronavirus disease (COVID-19), caused by SARS-CoV-2, a public
health emergency of international concern. In contrast to severe acute respiratory system …
China and the rest of the world are experiencing an outbreak of a novel betacoronavirus known as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). 1 By Feb 12, 2020, the rapid spread of the virus had caused 42 747 cases and 1017 deaths in China and cases have been reported in 25 countries, including the USA, Japan, and Spain. WHO has declared 2019 novel coronavirus disease (COVID-19), caused by SARS-CoV-2, a public health emergency of international concern. In contrast to severe acute respiratory system coronavirus and Middle East respiratory syndrome coronavirus, more deaths from COVID-19 have been caused by multiple organ dysfun ction syndrome rather than respiratory failure, 2 which might be attributable to the widespread distribution of angiotensin con verting enzyme 2—the functional receptor for SARS-CoV-2—in multiple organs. 3, 4 Patients with cancer are more susceptible to infection than individuals without cancer because of their systemic immunosuppressive state caused by the malignancy and anticancer treat ments, such as chemotherapy or surgery. 5–8 Therefore, these patients might be at increased risk of COVID-19 and have a poorer prognosis.
On behalf of the National Clinical Research Center for Respiratory Disease, we worked together with the National Health Commission of the People’s Republic of China to establish a prospective cohort to monitor COVID-19 cases throughout China. As of the data cutoff on Jan 31, 2020, we have collected and analysed 2007 cases from 575 hospitals (appendix pp 4–9 for a full list) in 31 provincial administrative regions. All cases were diagnosed with laboratory-confirmed COVID-19 acute respiratory disease and were admitted to hospital.
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