[HTML][HTML] Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model
Y Zhao, S Chen, P Lan, C Wu, Y Dou, X Xiao… - American journal of …, 2018 - Elsevier
Macrophages infiltrating the allografts are heterogeneous, consisting of proinflammatory (M1
cells) as well as antiinflammatory and fibrogenic phenotypes (M2 cells); they affect
transplantation outcomes via diverse mechanisms. Here we found that macrophage
polarization into M1 and M2 subsets was critically dependent on tumor necrosis factor
receptor–associated factor 6 (TRAF6) and mammalian target of rapamycin (mTOR),
respectively. In a heart transplant model we showed that macrophage-specific deletion of …
cells) as well as antiinflammatory and fibrogenic phenotypes (M2 cells); they affect
transplantation outcomes via diverse mechanisms. Here we found that macrophage
polarization into M1 and M2 subsets was critically dependent on tumor necrosis factor
receptor–associated factor 6 (TRAF6) and mammalian target of rapamycin (mTOR),
respectively. In a heart transplant model we showed that macrophage-specific deletion of …
