The proton-coupled folate transporter: physiological and pharmacological roles
R Zhao, ID Goldman - Current opinion in pharmacology, 2013 - Elsevier
Highlights•PCFT is the mechanism of intestinal absorption of folates and antifolates.•
Inactivating mutations of the PCFT gene result in hereditary folate malabsorption.•PCFT
activity is enhanced within the acidic microclimate of solid tumors.•PCFT is a potential route
for the selective delivery of antifolates to tumor cells.•PCFT plays a role in folate transport
across the choroid plexus.Recent studies have identified the proton-coupled folate
transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush …
Inactivating mutations of the PCFT gene result in hereditary folate malabsorption.•PCFT
activity is enhanced within the acidic microclimate of solid tumors.•PCFT is a potential route
for the selective delivery of antifolates to tumor cells.•PCFT plays a role in folate transport
across the choroid plexus.Recent studies have identified the proton-coupled folate
transporter (PCFT) as the mechanism by which folates are absorbed across the apical brush …