Hypopituitarism
ML Vance - New England Journal of Medicine, 1994 - Mass Medical Soc
ML Vance
New England Journal of Medicine, 1994•Mass Medical SocHypopituitarism may be either partial or complete and may result from either pituitary or
hypothalamic disease. Its clinical manifestations vary, depending on the extent and severity
of the pituitary hormone deficiency. Thus, a patient may present in extremis with acute
adrenal insufficiency or profound hypothyroidism, with symptoms indicating a pituitary mass
lesion, or with nonspecific symptoms of fatigue and malaise. Most of the hypothalamic-
pituitary-target-organ axes are tightly coordinated systems in which hormonal signals from …
hypothalamic disease. Its clinical manifestations vary, depending on the extent and severity
of the pituitary hormone deficiency. Thus, a patient may present in extremis with acute
adrenal insufficiency or profound hypothyroidism, with symptoms indicating a pituitary mass
lesion, or with nonspecific symptoms of fatigue and malaise. Most of the hypothalamic-
pituitary-target-organ axes are tightly coordinated systems in which hormonal signals from …
Hypopituitarism may be either partial or complete and may result from either pituitary or hypothalamic disease. Its clinical manifestations vary, depending on the extent and severity of the pituitary hormone deficiency. Thus, a patient may present in extremis with acute adrenal insufficiency or profound hypothyroidism, with symptoms indicating a pituitary mass lesion, or with nonspecific symptoms of fatigue and malaise.
Most of the hypothalamic-pituitary-target-organ axes are tightly coordinated systems in which hormonal signals from the hypothalamus stimulate or inhibit secretion of anterior pituitary hormones; these hormones, in turn, act on specific organs. These axes are frequently described as closed-loop or . . .
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