Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss
H Shen, B Zhang, JH Shin, D Lei, Y Du, X Gao, Q Wang… - Hearing research, 2007 - Elsevier
Cochlear noise injury is the second most frequent cause of sensorineural hearing loss, after
aging. Because calcium dysregulation is a widely recognized contributor to noise injury, we
examined the potential of calcium channel blockers to reduce noise-induced hearing loss
(NIHL) in mice. We focused on two T-type calcium blockers, trimethadione and
ethosuximide, which are anti-epileptics approved by the Food and Drug Administration.
Young C57BL/6 mice of either gender were divided into three groups: a 'prevention'group …
aging. Because calcium dysregulation is a widely recognized contributor to noise injury, we
examined the potential of calcium channel blockers to reduce noise-induced hearing loss
(NIHL) in mice. We focused on two T-type calcium blockers, trimethadione and
ethosuximide, which are anti-epileptics approved by the Food and Drug Administration.
Young C57BL/6 mice of either gender were divided into three groups: a 'prevention'group …
