[HTML][HTML] The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression: studies in ARNT-deficient cells
SM Wood, JM Gleadle, CW Pugh, O Hankinson… - Journal of Biological …, 1996 - ASBMB
Hypoxia-inducible factor-1 (HIF-1), a DNA-binding complex implicated in the regulation of
gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-
loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1α, and HIF-1β. One partner, HIF-1β,
had been recognized previously as the aryl hydrocarbon receptor nuclear translocator
(ARNT), an essential component of the xenobiotic response. In the present work, ARNT-
deficient mutant cells, originally derived from the mouse hepatoma line Hepa1c1c7, have …
gene expression by oxygen, has been shown to consist of a heterodimer of two basic helix-
loop-helix Per-AHR-ARNT-Sim (PAS) proteins, HIF-1α, and HIF-1β. One partner, HIF-1β,
had been recognized previously as the aryl hydrocarbon receptor nuclear translocator
(ARNT), an essential component of the xenobiotic response. In the present work, ARNT-
deficient mutant cells, originally derived from the mouse hepatoma line Hepa1c1c7, have …