Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
CW Pugh, BL Ebert, O Ebrahim, PJ Ratcliffe - Biochimica et Biophysica Acta …, 1994 - Elsevier
We have analysed sequences within the mouse erythropoietin enhancer which are required
for oxygen regulated operation in the erythropoietin producing cell line, HepG2, and in two
non-erythropoietin producing cell lines; the lung fibroblastoid cell line a23, and mouse
erythroleukaemia (MEL) cells. At least three critical sites were demonstrated within a 96
nucleotide sequence. Oxygen regulated operation was dependent on sites within the first 26
nucleotides. Sequences lying 3′ to this region modulated enhancer function but did not …
for oxygen regulated operation in the erythropoietin producing cell line, HepG2, and in two
non-erythropoietin producing cell lines; the lung fibroblastoid cell line a23, and mouse
erythroleukaemia (MEL) cells. At least three critical sites were demonstrated within a 96
nucleotide sequence. Oxygen regulated operation was dependent on sites within the first 26
nucleotides. Sequences lying 3′ to this region modulated enhancer function but did not …