Stem cells are characterized by the capacity for both self-renewal and generation of all other
cell types (pluripotency) or differentiated cells within a particular lineage (multipotency).
Stem cells are often localized to hypoxic niches within tissues and hypoxia inducible factors
(HIFs) play key roles in the maintenance of pluripotent and multipotent stem cells, as well as
cancer stem cells, which are also known as tumor-initiating cells. HIF inhibitors target cancer
stem cells and improve the responses to angiogenesis inhibitors and cytotoxic …