Transcription by RNA polymerase III: more complex than we thought
RJ White - Nature Reviews Genetics, 2011 - nature.com
Nature Reviews Genetics, 2011•nature.com
RNA polymerase (Pol) III is highly specialized for the production of short non-coding RNAs.
Once considered to be under relatively simple controls, recent studies using chromatin
immunoprecipitation followed by sequencing (ChIP–seq) have revealed unexpected levels
of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing
overlap with Pol II transcription. Here I describe these novel insights and consider their
implications and the questions that remain.
Once considered to be under relatively simple controls, recent studies using chromatin
immunoprecipitation followed by sequencing (ChIP–seq) have revealed unexpected levels
of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing
overlap with Pol II transcription. Here I describe these novel insights and consider their
implications and the questions that remain.
Abstract
RNA polymerase (Pol) III is highly specialized for the production of short non-coding RNAs. Once considered to be under relatively simple controls, recent studies using chromatin immunoprecipitation followed by sequencing (ChIP–seq) have revealed unexpected levels of complexity for Pol III regulation, including substantial cell-type selectivity and intriguing overlap with Pol II transcription. Here I describe these novel insights and consider their implications and the questions that remain.
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