To grow or not to grow: hair morphogenesis and human genetic hair disorders
O Duverger, MI Morasso - Seminars in cell & developmental biology, 2014 - Elsevier
O Duverger, MI Morasso
Seminars in cell & developmental biology, 2014•ElsevierMouse models have greatly helped in elucidating the molecular mechanisms involved in
hair formation and regeneration. Recent publications have reviewed the genes involved in
mouse hair development based on the phenotype of transgenic, knockout and mutant
animal models. While much of this information has been instrumental in determining
molecular aspects of human hair development and cycling, mice exhibit a specific pattern of
hair morphogenesis and hair distribution throughout the body that cannot be directly …
hair formation and regeneration. Recent publications have reviewed the genes involved in
mouse hair development based on the phenotype of transgenic, knockout and mutant
animal models. While much of this information has been instrumental in determining
molecular aspects of human hair development and cycling, mice exhibit a specific pattern of
hair morphogenesis and hair distribution throughout the body that cannot be directly …
Abstract
Mouse models have greatly helped in elucidating the molecular mechanisms involved in hair formation and regeneration. Recent publications have reviewed the genes involved in mouse hair development based on the phenotype of transgenic, knockout and mutant animal models. While much of this information has been instrumental in determining molecular aspects of human hair development and cycling, mice exhibit a specific pattern of hair morphogenesis and hair distribution throughout the body that cannot be directly correlated to human hair. In this mini-review, we discuss specific aspects of human hair follicle development and present an up-to-date summary of human genetic disorders associated with abnormalities in hair follicle morphogenesis, structure or regeneration.
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