Recent advances in the synthesis, design and selection of cysteine protease inhibitors
AA Hernandez, WR Roush - Current opinion in chemical biology, 2002 - Elsevier
AA Hernandez, WR Roush
Current opinion in chemical biology, 2002•ElsevierInhibition of cysteine proteases is emerging as an important strategy for the treatment of a
variety of human diseases. Intense efforts involving structure-based inhibitor design have
been directed toward several cysteine proteases, including cathepsin K, calpain, human
rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful
recent efforts have involved combinatorial synthesis and screening for identification of new
inhibitor templates.
variety of human diseases. Intense efforts involving structure-based inhibitor design have
been directed toward several cysteine proteases, including cathepsin K, calpain, human
rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful
recent efforts have involved combinatorial synthesis and screening for identification of new
inhibitor templates.
Inhibition of cysteine proteases is emerging as an important strategy for the treatment of a variety of human diseases. Intense efforts involving structure-based inhibitor design have been directed toward several cysteine proteases, including cathepsin K, calpain, human rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful recent efforts have involved combinatorial synthesis and screening for identification of new inhibitor templates.
Elsevier
