MicroRNA let-7c suppresses androgen receptor expression and activity via regulation of Myc expression in prostate cancer cells
N Nadiminty, R Tummala, W Lou, Y Zhu… - Journal of Biological …, 2012 - ASBMB
Castration-resistant prostate cancer continues to rely on androgen receptor (AR) expression.
AR plays a central role in the development of prostate cancer and progression to castration
resistance during and after androgen deprivation therapy. Here, we identified miR-let-7c as
a key regulator of expression of AR. miR-let-7c suppresses AR expression and activity in
human prostate cancer cells by targeting its transcription via c-Myc. Suppression of AR by let-
7c leads to decreased cell proliferation of human prostate cancer cells. Down-regulation of …
AR plays a central role in the development of prostate cancer and progression to castration
resistance during and after androgen deprivation therapy. Here, we identified miR-let-7c as
a key regulator of expression of AR. miR-let-7c suppresses AR expression and activity in
human prostate cancer cells by targeting its transcription via c-Myc. Suppression of AR by let-
7c leads to decreased cell proliferation of human prostate cancer cells. Down-regulation of …
