Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer.
T Kinoshita, S Nomoto, Y Kodera, M Koike… - Hepato …, 2011 - europepmc.org
T Kinoshita, S Nomoto, Y Kodera, M Koike, M Fujiwara, A Nakao
Hepato-gastroenterology, 2011•europepmc.orgResults A significant decrease in the expression of SFRP1 and SFRP5 was observed in
gastric cancer compared with corresponding normal gastric tissues. The SFRP1 gene was
hypermethylated in all 35 cancer tissues and corresponding non-cancerous tissues, as well
as all seven gastric cancer cell lines, whereas SFRP2 gene was methylated in 83% of
cancer tissues and 69% of normal epithelium, and SFRP5 in 43% and 54% of the same
groups, respectively. Although gender, age, tumor size, pathological type, depth of tumor …
gastric cancer compared with corresponding normal gastric tissues. The SFRP1 gene was
hypermethylated in all 35 cancer tissues and corresponding non-cancerous tissues, as well
as all seven gastric cancer cell lines, whereas SFRP2 gene was methylated in 83% of
cancer tissues and 69% of normal epithelium, and SFRP5 in 43% and 54% of the same
groups, respectively. Although gender, age, tumor size, pathological type, depth of tumor …
Results
A significant decrease in the expression of SFRP1 and SFRP5 was observed in gastric cancer compared with corresponding normal gastric tissues. The SFRP1 gene was hypermethylated in all 35 cancer tissues and corresponding non-cancerous tissues, as well as all seven gastric cancer cell lines, whereas SFRP2 gene was methylated in 83% of cancer tissues and 69% of normal epithelium, and SFRP5 in 43% and 54% of the same groups, respectively. Although gender, age, tumor size, pathological type, depth of tumor and TNM stage were not significantly correlated with the expression of SFRP genes, a significant decrease in the SFRP1 expression score was observed among gastric cancer with lymph node metastasis.
Conclusion
These results indicate the possibility that SFRP1 and 5 genes function as tumor suppressors, the down-regulation of which not only contributes to carcinogenesis but is also associated to some extent with the metastatic potential of cancer cells.
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