Trypanosoma cruzi: treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice
JM Arantes, ML Pedrosa, HR Martins, VM Veloso… - Experimental …, 2007 - Elsevier
The effects of prolonged treatment with iron chelator (desferrioxamine) on the development
of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated
mice presented lower levels of parasitemia and reduced mortality rate compared with
infected/non-treated animals. The five out of twenty infected/treated mice that survived the
acute phase of infection showed negative hemoculture and positive ELISA in the acute and
chronic phases and positive PCR in the acute phase: in the chronic phase, three of the …
of infection in mice inoculated with Y Trypanosoma cruzi were determined. Infected/treated
mice presented lower levels of parasitemia and reduced mortality rate compared with
infected/non-treated animals. The five out of twenty infected/treated mice that survived the
acute phase of infection showed negative hemoculture and positive ELISA in the acute and
chronic phases and positive PCR in the acute phase: in the chronic phase, three of the …
