[HTML][HTML] Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways
Unlike the prototype transforming growth factor-β (TGF-β), bone morphogenetic protein-6
(BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6
in macrophages. Using overexpression and knockdown experiments, we demonstrate that
BMP receptor type II and activin-like kinase-2 are necessary for IL-6 induction by BMP-6. At
the intracellular level, both Smad and p38 signaling pathways are required for the induction
of IL-6. The cross-talk between the two pathways occurs at the level of transcription factor …
(BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6
in macrophages. Using overexpression and knockdown experiments, we demonstrate that
BMP receptor type II and activin-like kinase-2 are necessary for IL-6 induction by BMP-6. At
the intracellular level, both Smad and p38 signaling pathways are required for the induction
of IL-6. The cross-talk between the two pathways occurs at the level of transcription factor …
