Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons
LC McKay, WA Janczewski, JL Feldman - Nature neuroscience, 2005 - nature.com
LC McKay, WA Janczewski, JL Feldman
Nature neuroscience, 2005•nature.comAblation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm
generation, resulted in a progressive, increasingly severe disruption of respiratory pattern,
initially during sleep and then also during wakefulness in adult rats. Sleep-disordered
breathing is highly prevalent in elderly humans and in some patients with
neurodegenerative disease. We propose that sleep-disordered breathing results from loss of
preBötC neurons and could underlie death during sleep in these populations.
generation, resulted in a progressive, increasingly severe disruption of respiratory pattern,
initially during sleep and then also during wakefulness in adult rats. Sleep-disordered
breathing is highly prevalent in elderly humans and in some patients with
neurodegenerative disease. We propose that sleep-disordered breathing results from loss of
preBötC neurons and could underlie death during sleep in these populations.
Abstract
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
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