A feat of metabolic proportions: Pdx1 orchestrates islet development and function in the maintenance of glucose homeostasis
DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier
Emerging evidence over the past decade indicates a central role for transcription factors in
the embryonic development of pancreatic islets and the consequent maintenance of normal
glucose homeostasis. Pancreatic and duodenal homeobox 1 (Pdx1) is the best studied and
perhaps most important of these factors. Whereas deletion or inactivating mutations of the
Pdx1 gene causes whole pancreas agenesis in both mice and humans, even
haploinsufficiency of the gene or alterations in its expression in mature islet cells causes …
the embryonic development of pancreatic islets and the consequent maintenance of normal
glucose homeostasis. Pancreatic and duodenal homeobox 1 (Pdx1) is the best studied and
perhaps most important of these factors. Whereas deletion or inactivating mutations of the
Pdx1 gene causes whole pancreas agenesis in both mice and humans, even
haploinsufficiency of the gene or alterations in its expression in mature islet cells causes …
