Detection of circulating B cells secreting platelet-specific autoantibody is useful in the diagnosis of autoimmune thrombocytopenia
M Kuwana, Y Okazaki, J Kaburaki… - The American journal of …, 2003 - amjmed.com
Methods We examined 78 patients with chronic ITP, 32 patients with thrombocytopenia due
to nonautoimmune thrombocytopenia (18 with myelodysplastic syndrome, 6 with aplastic
anemia, 5 with thrombotic thrombocytopenic purpura, and 3 with disseminated intravascular
coagulation), and 52 healthy blood donors. The diagnosis of chronic ITP was based on
thrombocytopenia (platelet count< 50× 10 9/L) for at least 6 months, normal or increased
bone marrow megakaryocytes without morphological evidence of dysplasia, and no …
to nonautoimmune thrombocytopenia (18 with myelodysplastic syndrome, 6 with aplastic
anemia, 5 with thrombotic thrombocytopenic purpura, and 3 with disseminated intravascular
coagulation), and 52 healthy blood donors. The diagnosis of chronic ITP was based on
thrombocytopenia (platelet count< 50× 10 9/L) for at least 6 months, normal or increased
bone marrow megakaryocytes without morphological evidence of dysplasia, and no …
