[HTML][HTML] Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
M Navab, SY Hama, GM Anantharamaiah… - Journal of lipid …, 2000 - ASBMB
Treatment of human artery wall cells with apolipoprotein AI (apoA-I), but not apoA-II, with an
apoA-I peptide mimetic, or with high density lipoprotein (HDL), or paraoxonase, rendered
the cells unable to oxidize low density lipoprotein (LDL). Human aortic wall cells were found
to contain 12-lipoxygenase (12-LO) protein. Transfection of the cells with antisense to 12-LO
(but not sense) eliminated the 12-LO protein and prevented LDL-induced monocyte
chemotactic activity. Addition of 13 (S)-hydroperoxyoctadecadienoic acid [13 (S)-HPODE] …
apoA-I peptide mimetic, or with high density lipoprotein (HDL), or paraoxonase, rendered
the cells unable to oxidize low density lipoprotein (LDL). Human aortic wall cells were found
to contain 12-lipoxygenase (12-LO) protein. Transfection of the cells with antisense to 12-LO
(but not sense) eliminated the 12-LO protein and prevented LDL-induced monocyte
chemotactic activity. Addition of 13 (S)-hydroperoxyoctadecadienoic acid [13 (S)-HPODE] …