OBJECTIVE: Adrenomedullin is increased in maternal plasma in pregnancy and has been
found in very high concentrations in amniotic fluid and umbilical plasma. To identify
adrenomedullin-producing tissue in pregnancy we measured adrenomedullin concentration
and distribution in fetoplacental tissues. STUDY DESIGN: By use of a specific
radioimmunoassay we determined the concentrations of adrenomedullin and, by
immunohistochemical studies, its localization and distribution in fetal membranes and …