[HTML][HTML] Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2 …
AJ Janecki, MH Montrose, P Zimniak… - Journal of Biological …, 1998 - ASBMB
Na+/H+ exchanger isoform 3 (NHE3), an epithelial brush border isoform of the Na+/H+
exchanger gene family, plays an important role in reabsorption of Na+ in the small intestine,
the colon, and the kidney. In several cell types, phorbol 12-myristate 13-acetate (PMA)
acutely inhibits NHE3 activity by changes in V max, but the mechanism of this inhibition is
unknown. We investigated the role of subcellular redistribution of NHE3 in the PMA-induced
inhibition of endogenous brush border NHE3 in a model human colon adenocarcinoma cell …
exchanger gene family, plays an important role in reabsorption of Na+ in the small intestine,
the colon, and the kidney. In several cell types, phorbol 12-myristate 13-acetate (PMA)
acutely inhibits NHE3 activity by changes in V max, but the mechanism of this inhibition is
unknown. We investigated the role of subcellular redistribution of NHE3 in the PMA-induced
inhibition of endogenous brush border NHE3 in a model human colon adenocarcinoma cell …
