Intracytoplasmic sperm injection (ICSI) pregnancies have an increased risk of sex chromosome abnormalities, but not of de-novo autosomal rearrangements. 1, 2 Only one case of trisomy 21 has been reported in a woman aged 41 years. 1 We report the prenatal diagnosis of a fetus with two denovo balanced chromosomal translocations, 45, XX, t (2; 6)(p; q),–14;–21; t (14q; 21), in an ICSI pregnancy. The patient, a woman aged 32 years, underwent amniocentesis at 17 weeks’ gestation after genetic counselling. Parental karotypes were normal, which shows de-novo origin of the two chromosome rearrangements in the fetus. Ultrasonography at 24 weeks showed no malformations, but fetal measurements were 2 weeks smaller than expected.

Complex chromosome rearrangements (CCR) are rare—only ten cases have been diagnosed prenatally. Congenital anomalies were present in three cases, and mental retardation of delayed development in two cases. Only three fetuses developed normally. Four pregnancies were terminated. 3, 4 On the basis of these data and suspected