Antigen recognition determinants of γδ T cell receptors
Science, 2005•science.org
The molecular basis of γδ T cell receptor (TCR) recognition is poorly understood. Here, we
analyze the TCR sequences of a natural γδ T cell population specific for the major
histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates
strongly with a somatically recombined TCRδ complementarity-determining region 3 (CDR3)
motif derived from germ line–encoded residues. Sequence diversity around these residues
modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with …
analyze the TCR sequences of a natural γδ T cell population specific for the major
histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates
strongly with a somatically recombined TCRδ complementarity-determining region 3 (CDR3)
motif derived from germ line–encoded residues. Sequence diversity around these residues
modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with …
The molecular basis of γδ T cell receptor (TCR) recognition is poorly understood. Here, we analyze the TCR sequences of a natural γδ T cell population specific for the major histocompatibility complex class Ib molecule T22. We find that T22 recognition correlates strongly with a somatically recombined TCRδ complementarity-determining region 3 (CDR3) motif derived from germ line–encoded residues. Sequence diversity around these residues modulates TCR ligand-binding affinities, whereas V gene usage correlates mainly with tissue origin. These results show how an antigen-specific γδ TCR repertoire can be generated at a high frequency and suggest that γδ T cells recognize a limited number of antigens.
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