STAT3 and STAT5B Are Targets of Two Different Signal Pathways Activated by Hematopoietin Receptors and Control Transcription via Separate Cytokine Response …
CF Lai, J Ripperger, KK Morella, Y Wang… - Journal of Biological …, 1995 - ASBMB
Transient transfection of expression vectors for various members of the hematopoietin
receptor family and STAT proteins into COS-1 cells indicated that each receptor was
capable of stimulating the DNA binding activity of STAT1, STAT3, and STAT5B. However,
gp130 preferentially activated STAT1 and STAT3. Activation of STAT5B differed from that of
the other two in that the box 3 sequence motif in the cytoplasmic domain of gp130 was not
required. Moreover, STAT5B and STAT3 enhanced gene transcription via separate …
receptor family and STAT proteins into COS-1 cells indicated that each receptor was
capable of stimulating the DNA binding activity of STAT1, STAT3, and STAT5B. However,
gp130 preferentially activated STAT1 and STAT3. Activation of STAT5B differed from that of
the other two in that the box 3 sequence motif in the cytoplasmic domain of gp130 was not
required. Moreover, STAT5B and STAT3 enhanced gene transcription via separate …
