[HTML][HTML] L-selectin signaling of neutrophil adhesion and degranulation involves p38 mitogen-activated protein kinase
JE Smolen, TK Petersen, C Koch, SJ O'Keefe… - Journal of Biological …, 2000 - ASBMB
The adhesion molecules known as selectins mediate the capture of neutrophils from the
bloodstream. We have previously reported that ligation and cross-linking of L-selectin on the
neutrophil surface enhances the adhesive function of β 2-integrins in a synergistic manner
with chemotactic agonists. In this work, we examined degranulation and adhesion of
neutrophils in response to cross-linking of L-selectin and addition of interleukin-8. Cross-
linking of L-selectin induced priming of degranulation that was similar to that observed with …
bloodstream. We have previously reported that ligation and cross-linking of L-selectin on the
neutrophil surface enhances the adhesive function of β 2-integrins in a synergistic manner
with chemotactic agonists. In this work, we examined degranulation and adhesion of
neutrophils in response to cross-linking of L-selectin and addition of interleukin-8. Cross-
linking of L-selectin induced priming of degranulation that was similar to that observed with …
